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Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
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Document Title
Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
Author
Klinngam W.,Rungkamoltip P.,Thongin S.,Joothamongkhon J.,Khumkhrong P.,Khongkow M.,Namdee K.,Tepaamorndech S.,Chaikul P.,Kanlayavattanakul M.,Lourith N.,Piboonprai K.,Ruktanonchai U.,Asawapirom U.,Iempridee T.
Name from Authors Collection
Scopus Author ID
57220746701
Affiliations
National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency, Pathum Thani, 12120, Thailand; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, 12120, Thailand; Phytocosmetics and Cosmeceuticals Research Group, School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, Thailand; School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand; Laboratory of Host Defense, The World Premier International Research Center Initiative (WPI), Immunology Frontier Research Center (IFReC), Osaka University, Osaka, 565–0871, Japan
Type
Article
Source Title
Biomedicine and Pharmacotherapy
ISSN
07533322
Year
2022
Volume
145
Open Access
All Open Access, Gold
Publisher
Elsevier Masson s.r.l.
DOI
10.1016/j.biopha.2021.112461
Abstract
Skin aging is accompanied by an increase in the number of senescent cells, resulting in various pathological outcomes. These include inflammation, impaired barrier function, and susceptibility to skin disorders such as cancer. Kaempferia parviflora (Thai black ginger), a medicinal plant native to Thailand, has been shown to counteract inflammation, cancer, and senescence. This study demonstrates that polymethoxyflavones (5,7-dimethoxyflavone, 5,7,4′-trimethoxyflavone, and 3,5,7,3′,4′-pentamethoxyflavone) purified from K. parviflora rhizomes suppressed cellular senescence, reactive oxygen species, and the senescence-associated secretory phenotype in primary human dermal fibroblasts. In addition, they increased tropocollagen synthesis and alleviated free radical-induced cellular and mitochondrial damage. Moreover, the compounds mitigated chronological aging in a human ex vivo skin model by attenuating senescence and restoring expression of essential components of the extracellular matrix, including collagen type I, fibrillin-1, and hyaluronic acid. Finally, we report that polymethoxyflavones enhanced epidermal thickness and epidermal-dermal stability, while blocking age-related inflammation in skin explants. Our findings support the use of polymethoxyflavones from K. parviflora as natural anti-aging agents, highlighting their potential as active ingredients in cosmeceutical and nutraceutical products. © 2021 The Authors
Keyword
ex vivo | Kaempferia parviflora | Polymethoxyflavone | Senescence | Skin aging
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
Mae Fah Luang University; National Nanotechnology Center
License
CC BY-NC-ND
Rights
Elsevier B.V.
Publication Source
Scopus