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Preparation and characterization of nanoparticles from quaternized cyclodextrin-grafted chitosan associated with hyaluronic acid for cosmetics
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Document Title
Preparation and characterization of nanoparticles from quaternized cyclodextrin-grafted chitosan associated with hyaluronic acid for cosmetics
Author
Sakulwech S., Lourith N., Ruktanonchai U., Kanlayavattanakul M.
Name from Authors Collection
Scopus Author ID
57203023869
Affiliations
School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai, 57100, Thailand; National Nanotechnology Center, National Science and Technology Development Agency, Pathum Thani, 12120, Thailand
Type
Article
Source Title
Asian Journal of Pharmaceutical Sciences
ISSN
18180876
Year
2018
Volume
13
Issue
5
Page
498-504
Open Access
All Open Access, Gold, Green
Publisher
Shenyang Pharmaceutical University
DOI
10.1016/j.ajps.2018.05.006
Format
Abstract
Hyaluronic acid (HA, 20–50 kDa) is a hydrophilic macromolecule with anti-wrinkle effects and moisturizing properties. However, its high molecular weight prevents it from penetrating into the deeper layers of the skin and, thus, limits its benefits to topical effects. Thus, the objective of this study is to prepare nanoparticles of quaternized cyclodextrin-grafted chitosan (QCD-g-CS) associated with HA in different molar ratios of QCD-g-CS and HA. The conjugation of the carboxylic moieties of HA and the amides of QCD-g-CS was confirmed by Fourier-transform infrared spectroscopy. Thus, the system was optimized to create nanoparticles with a small size (235.63 ± 21.89 nm), narrow polydispersity index (0.13 ± 0.02), and zeta potential of 16.07 ± 0.65 mV. The association efficiency and loading efficiency were determined by ultra-performance liquid chromatography as 86.77 ± 0.69% and 10.85 ± 0.09%, respectively. The spherical morphology of the obtained nanoparticles was confirmed by transmission electron microscopy. Moreover, the in-vitro hydrating ability was significantly higher (P < 0.001) than that of bulk HA (3.29 ± 0.41 and 1.71 ± 0.05 g water/g sample, respectively). The safety of these nanoparticles at concentrations in the range of 0.01–0.10 mg/ml was confirmed via tests on human skin fibroblasts. Together, these results demonstrate that the developed nanoparticles are promising for future applications in cosmetics. © 2018 Shenyang Pharmaceutical University
Keyword
Delivery system | Hyaluronic acid | Ionic gelation | Polymeric nanoparticles | QCD-g-CS
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
National Science and Technology Development Agency; National Nanotechnology Center; Thailand Graduate Institute of Science and Technology
License
CC BY-NC-ND
Rights
Author
Publication Source
Scopus