• Preparation of [18F]-NHC-BF3 conjugates and their applications in PET imaging

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Metadata

Document Title

Preparation of [18F]-NHC-BF3 conjugates and their applications in PET imaging

Author

Chansaenpak K., Wang M., Wang H., Giglio B.C., Gabbaï F.P., Wu Z., Li Z.

Name from Authors Collection

Kantapat Chansaenpak

Scopus Author ID

36863405900

ORCID ID

0000-0002-5462-9897

|

Wang M.

Scopus Author ID

56199035100

ORCID ID

NULL

|

Wang H.

Scopus Author ID

24342544400

ORCID ID

NULL

|

Giglio B.C.

Scopus Author ID

23990449700

ORCID ID

NULL

|

Gabbaï F.P.

Scopus Author ID

35556832900

ORCID ID

NULL

|

Wu Z.

Scopus Author ID

16837568200

ORCID ID

NULL

|

Li Z.

Scopus Author ID

25938366300

ORCID ID

NULL

Affiliations

Biomedical Research Imaging Center, Department of Radiology, University of North Carolina, Chapel Hill, NC 27514, United States; Department of Chemistry, Texas A and M University, College Station, TX 77843, United States; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Pathum Thani, 12120, Thailand

Type

Article

Source Title

RSC Advances

ISSN

20462069

Year

2017

Volume

7

Issue

29

Page

17748-17751

Open Access

Gold, Green

Publisher

Royal Society of Chemistry

DOI

10.1039/c6ra28806e

Abstract

N-Heterocyclic carbene boron trifluoride (NHC-BF3) conjugates were successfully radiofluorinated by SnCl4-promoted 18F-19F isotopic exchange reaction in one labelling step. This method afforded in vivo stable PET agents that efficiently bound to targeted tumours yielding PET images with good tumour-to-background contrast. © The Royal Society of Chemistry.

Funding Sponsor

National Cancer Institute; University of North Carolina; U.S. Public Health Service

License

CC BY-NC

Rights

Author

Publication Source

Scopus

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