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Preparation of [F-18]-NHC-BF3 conjugates and their applications in PET imaging
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Document Title
Preparation of [F-18]-NHC-BF3 conjugates and their applications in PET imaging
Author
Chansaenpak K, Wang MZ, Wang H, Giglio BC, Gabba FP, Wu ZH, Li ZB
Name from Authors Collection
Affiliations
University of North Carolina; University of North Carolina Chapel Hill; Texas A&M University System; Texas A&M University College Station; National Science & Technology Development Agency - Thailand; National Nanotechnology Center (NANOTEC)
Type
Article
Source Title
RSC ADVANCES
ISSN
2046-2069
Year
2017
Volume
7
Issue
29
Page
17748-17751
Open Access
gold, Green Published
Publisher
ROYAL SOC CHEMISTRY
DOI
10.1039/c6ra28806e
Format
Abstract
N-Heterocyclic carbene boron trifluoride (NHC-BF3) conjugates were successfully radiofluorinated by SnCl4-promoted F-18-F-19 isotopic exchange reaction in one labelling step. This method afforded in vivo stable PET agents that efficiently bound to targeted tumours yielding PET images with good tumour-to-background contrast.
Funding Sponsor
National Cancer Institute [P30-CA016086-35-37]; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill
Publication Source
WOS