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Printable-Microencapsulated Ascorbic Acid for Personalized Topical Delivery
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Document Title
Printable-Microencapsulated Ascorbic Acid for Personalized Topical Delivery
Author
Vayachuta L. Leang M. Ruamcharoen J. Thiramanas R. Prateepchinda S. Prompinit P. Du-A-man S. Wisutthathum S. Waranuch N.
Affiliations
National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA) Pathum Thani Khlong Luang 12120 Thailand; Faculty of Science and Technology Prince of Songkla University Pattani Muang 94000 Thailand; Cosmetics and Natural Products Research Center Faculty of Pharmaceutical Sciences Naresuan University Phitsanulok 65000 Thailand
Type
Article
Source Title
ACS Applied Bio Materials
ISSN
25766422
Year
2023
Volume
6
Issue
12
Page
5385-5398
Open Access
All Open Access Hybrid Gold Green
Publisher
American Chemical Society
DOI
10.1021/acsabm.3c00648
Abstract
This study presents the successful development of printable-microencapsulated ascorbic acid (AA) for personalized topical delivery using laser printing technology. Rice flour with a 10% AA content was selected as an encapsulation material. Hydrophobic nanosilica was used to create negative electrostatic charges on the microencapsulated surfaces via a high-speed mixture. This process facilitated the microencapsulated AA fabrication using a commercial laser printer and produced a well-patterned design with some minor print defects such as banding and scattering. The amount of encapsulated AA per area was 0.28 mg/cm2 and the RGB color code was 0 0 0. An emulsion carrier system comprising pentylene glycol (P5G) or diethylene glycol monoethyl ether (DEGEE) Tween 20 oleic acid and deionized (DI) water at a ratio of 20:30:30:20 was developed to enhance AA transmission into the skin. The Franz diffusion cell technique was used to investigate topical absorption on Strat-M membranes using P5G and DEGEE as enhancers. The steady-state fluxes were 8.40 (?0.64) and 10.04 (?0.58) ?g/h/cm2 for P5G and DEGEE respectively. Cytotoxicity tests conducted on fibroblast cells revealed low cytotoxicity for the encapsulation products and carriers. ? 2023 American Chemical Society.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
CC by
Rights
American Chemical Society
Publication Source
Scopus