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Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform
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Document Title
Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform
Author
Sa-nguanmoo N, Namdee K, Khongkow M, Ruktanonchai U, Zhao YX, Liang XJ
Name from Authors Collection
Affiliations
Chinese Academy of Sciences; National Center for Nanoscience & Technology - China; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; National Science & Technology Development Agency - Thailand; National Nanotechnology Center (NANOTEC); Guangxi Medical University
Type
Review
Source Title
NANO RESEARCH
Year
2022
Volume
15
Issue
3
Page
2196-2225
Open Access
Green Published, Bronze
Publisher
TSINGHUA UNIV PRESS
DOI
10.1007/s12274-021-3832-y
Format
Abstract
Vaccination is the most effective way to prevent coronavirus disease 2019 (COVID-19). Vaccine development approaches consist of viral vector vaccines, DNA vaccine, RNA vaccine, live attenuated virus, and recombinant proteins, which elicit a specific immune response. The use of nanoparticles displaying antigen is one of the alternative approaches to conventional vaccines. This is due to the fact that nano-based vaccines are stable, able to target, form images, and offer an opportunity to enhance the immune responses. The diameters of ultrafine nanoparticles are in the range of 1-100 nm. The application of nanotechnology on vaccine design provides precise fabrication of nanomaterials with desirable properties and ability to eliminate undesirable features. To be successful, nanomaterials must be uptaken into the cell, especially into the target and able to modulate cellular functions at the subcellular levels. The advantages of nano-based vaccines are the ability to protect a cargo such as RNA, DNA, protein, or synthesis substance and have enhanced stability in a broad range of pH, ambient temperatures, and humidity for long-term storage. Moreover, nano-based vaccines can be engineered to overcome biological barriers such as nonspecific distribution in order to elicit functions in antigen presenting cells. In this review, we will summarize on the developing COVID-19 vaccine strategies and how the nanotechnology can enhance antigen presentation and strong immunogenicity using advanced technology in nanocarrier to deliver antigens. The discussion about their safe, effective, and affordable vaccines to immunize against COVID-19 will be highlighted.
Keyword
antigen presenting cells (APCs) | COVID-19 | nanotechnology | SARS-CoV-2 | vaccine
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
OCSC Royal Thai Government UCAS Scholarship; National Nanotechnology Center (NANOTEC), Thailand [P1852764]; National Center for Nanoscience and Technology, China [P1852764]; National Natural Science Foundation of China (NSFC) key projects [31630027, 32030060]; NSFC international collaboration key project [51861135103]; NSFC-German Research Foundation (DFG) project [31761133013]; Beijing-Tianjin-Hebei Basic Research Cooperation Project [19JCZDJC64100]; National Key Research AMP; Development Program of China [2018YFE0117800]
License
Copyright
Rights
Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform
Publication Source
WOS