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Studies on the biologically active secondary metabolites of the new spider parasitic fungus Gibellula gamsii
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Document Title
Studies on the biologically active secondary metabolites of the new spider parasitic fungus Gibellula gamsii
Author
Kuephadungphan W., Macabeo A.P.G., Luangsa-ard J.J., Tasanathai K., Thanakitpipattana D., Phongpaichit S., Yuyama K., Stadler M.
Name from Authors Collection
Scopus Author ID
35604975600
Scopus Author ID
37102962800
Affiliations
Department Microbial Drugs, Helmholtz Centre for Infection Research, and partner site Hannover/Braunschweig of the German Centre for Infection Research (DZIF), Inhoffenstrasse 7, Braunschweig, 38124, Germany; Department of Microbiology, Faculty of Science, Prince of Songkla University, Karnjanavanit Road 15, Songkhla, 90110, Thailand; Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Espana St., Manila, 1015, Philippines; Microbe Interaction and Ecology Laboratory, National Centre for Genetic Engineering and Biotechnology (BIOTEC), NSTDA, 113 Thailand Science Park, Phahonyothin Road, Klong Nueng, Klong Luang, Pathum Thani, 12120, Thailand
Type
Article
Source Title
Mycological Progress
ISSN
1617416X
Year
2019
Volume
18
Issue
1-ก.พ.
Page
135-146
Open Access
Hybrid Gold, Green
Publisher
Springer Verlag
DOI
10.1007/s11557-018-1431-4
Abstract
Numerous gatherings of a new species of the genus Gibellula, closely resembling the monotypic, neotropical G. mirabilis were encountered in Thailand. The taxon was cultured successfully although no in vitro sporulation was observed. The new species, Gibellula gamsii, could be distinguished from closely related other Gibellula species on the basis of morphological features and phylogenetic inferences recruiting concatenated sequences of five DNA loci including ITS, LSU, RPB1, RPB2, and EF1-α. The secondary metabolites of G. gamsii, strain BCC47868, were studied concurrently after preparative separation of the crude extract by preparative high-performance liquid chromatography (HPLC). Two new 1,3-disubstituted β-carboline alkaloids, for which we propose the trivial names, gibellamines A (1) and B (2), were isolated. The chemical structures of these compounds were elucidated by interpretation of spectral data, generated by nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS). The alkaloid 1 also exhibited moderate anti-biofilm activity against Staphylococcus aureus. © 2018, The Author(s).
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
Horizon 2020 Framework Programme
License
CC BY
Rights
Author
Publication Source
Scopus