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Studies on the chemical constituents of stem bark of Millettia leucantha: Isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities
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Document Title
Studies on the chemical constituents of stem bark of Millettia leucantha: Isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities
Author
Phrutivorapongkul A, Lipipun V, Ruangrungsi N, Kirtikara K, Nishikawa K, Maruyama S, Watanabe T, Ishikawa T
Name from Authors Collection
Affiliations
Chulalongkorn University; National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC); Nippon Kayaku Co., Ltd.; Chiba University
Type
Article
Source Title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN
0009-2363
Year
2003
Volume
51
Issue
2
Page
187-190
Open Access
Bronze
Publisher
PHARMACEUTICAL SOC JAPAN
DOI
10.1248/cpb.51.187
Format
Abstract
Four new chalcone derivatives (1, 4, 7, 10) were isolated from the stem bark of Millettia leucantha K-URZ (Leguminosae) along with two known ones (2, 6) and five known flavones (3, 5, 8, 9, 11). Structure elucidation and unambiguous assignment of the isolates were achieved with the aid of 1D and 2D NMR extensive studies. Correlation of 10 to 4 was successfully done by reduction with Et3SiH/CF3CO2H. Moderate cytotoxic activity was observed in chalcones (1,10), whereas dihydrochalcones (4, 6) showed moderate anti-Herpes Simplex Virus (HSV) activity. Interestingly, flavone 8 showed significant anti-inflammatory effects inhibiting both cyclooxygenase (COX)-1 and -2.
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WOS