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Tenellin acts as an iron chelator to prevent iron-generated reactive oxygen species toxicity in the entomopathogenic fungus Beauveria bassiana
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Document Title
Tenellin acts as an iron chelator to prevent iron-generated reactive oxygen species toxicity in the entomopathogenic fungus Beauveria bassiana
Author
Jirakkakul J., Cheevadhanarak S., Punya J., Chutrakul C., Senachak J., Buajarern T., Tanticharoen M., Amnuaykanjanasin A.
Name from Authors Collection
Scopus Author ID
56993955700
Affiliations
School of Bioresources and Technology, King Mongkut's University of Technology Thonburi (KMUTT), Bangkok, 10140, Thailand; Bioresources Technology Unit, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani, 12120, Thailand
Type
Article
Source Title
FEMS Microbiology Letters
ISSN
03781097
Year
2015
Volume
362
Issue
2
Open Access
All Open Access, Bronze, Green
Publisher
Oxford University Press
DOI
10.1093/femsle/fnu032
Format
Abstract
Iron is an essential element for life. However, the iron overload can be toxic. Here, we investigated the significant increase of tenellin and iron-tenellin complex production in ferricrocin-deficient mutants of Beauveria bassiana. Our chemical analysis indicated that the ferricrocin-deficient mutants T1, T3 and T5 nearly abolished ferricrocin production. In turn, these mutants had significant accumulation of iron-tenellin complex in their mycelia at 247-289 mg g-1 cell dry weight under iron-replete condition. Both tenellin and iron-tenellin complex were not detected in the wild-type under such condition. Mass analysis of the mutants' crude extracts demonstrated that tenellin formed a 3:1 complex with iron in the absence of ferricrocin. The unexpected link between ferricrocin and tenellin biosynthesis in ferricrocin-deficient mutants could be a survival strategy during iron-mediated oxidative stress. © 2014 FEMS.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
N/A
Rights
N/A
Publication Source
Scopus