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The avian influenza virus PA segment mediates strain-specific antagonism of BST-2/tetherin
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Document Title
The avian influenza virus PA segment mediates strain-specific antagonism of BST-2/tetherin
Author
Narkpuk J., Jongkaewwattana A., Teeravechyan S.
Name from Authors Collection
Scopus Author ID
55279790400
Affiliations
Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park Phaholyothin Rd, Klong 1, Klong Luang, Pathumthani, 12120, Thailand
Type
Article
Source Title
Virology
ISSN
00426822
Year
2018
Volume
525
Page
161-169
Open Access
All Open Access, Bronze, Green
Publisher
Academic Press Inc.
DOI
10.1016/j.virol.2018.09.016
Format
Abstract
BST-2 is an antiviral protein described as a powerful cross-species transmission barrier for simian immunodeficiency viruses. Influenza viruses appear to interact with BST-2, raising the possibility that BST-2 may be a barrier for cross-species transmission. An MDCK-based cell line expressing human BST-2 was generated to study human-derived A/Puerto Rico/8/36 (H1N1; PR8) as well as two low pathogenic avian influenza viruses (subtypes H4N6 and H6N1). The H4N6 and H6N1 viruses were less affected by BST-2 expression than PR8, due to their ability to decrease BST-2 levels, a function localized to the PA segment of both avian viruses. Experiments with PA-mutant and -chimeric viruses confirmed that the avian PA segment conferred BST-2 downregulation and antagonism. These results indicate a species-specific ability of PA from low pathogenic avian viruses to mitigate human BST-2 antiviral activity, suggesting that BST-2 is unlikely to be a general cross-species barrier to transmission of such viruses to humans. © 2018 Elsevier Inc.
Keyword
Avian influenza | BST-2 | Influenza virus | NS1 | PA | PA-X | Tetherin
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
St. Jude Children's Research Hospital; Armed Forces Research Institute of Medical Sciences; Mahidol University; Ministry of Public Health; National Center for Genetic Engineering and Biotechnology
License
N/A
Rights
N/A
Publication Source
Scopus