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Water-soluble metalated covalent organic nanobelts with improved bioavailability for protein transportation
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Document Title
Water-soluble metalated covalent organic nanobelts with improved bioavailability for protein transportation
Author
Kong W., Wan J., Namuangruk S., Guo J., Wang C.
Name from Authors Collection
Affiliations
Department of Macromolecular Science, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China; National Nanotechnology Center (NaNOTEC), National Science and Technology Development agency, Pathumthani, 12120, Thailand
Type
Article
Source Title
Scientific Reports
ISSN
20452322
Year
2018
Volume
8
Issue
1
Open Access
All Open Access, Gold, Green
Publisher
Nature Publishing Group
DOI
10.1038/s41598-018-23744-1
Format
Abstract
an available pathway to prepare the ionized covalent organic nanosheets (iCONs) has been proposed by a metal-assisted aqueous-phase exfoliation route from covalent organic frameworks. The soluble and belt-shaped iCONs could immobilize a large quantity of proteins (2.73 mg/mg, BSa/iCONs) and hence serve as transporters to enhance the protein uptake by cancer cells. Meanwhile, their energy-dependent endocytosis pathway via clathrin-coated pits has been proved as well. © 2018 The author(s).
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
National Natural Science Foundation of China; Science and Technology Commission of Shanghai Municipality
License
CC BY
Rights
Author
Publication Source
Scopus