• Water-soluble metalated covalent organic nanobelts with improved bioavailability for protein transportation

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Document Title

Water-soluble metalated covalent organic nanobelts with improved bioavailability for protein transportation

Author

Kong W., Wan J., Namuangruk S., Guo J., Wang C.

Name from Authors Collection

Kong W.

Scopus Author ID

57191472682

ORCID ID

NULL

|

Wan J.

Scopus Author ID

56034851500

ORCID ID

NULL

|

Namuangruk S.

Scopus Author ID

6506435474

ORCID ID

0000-0003-2087-6707

|

Guo J.

Scopus Author ID

56199443900

ORCID ID

NULL

|

Wang C.

Scopus Author ID

8911967800

ORCID ID

NULL

Affiliations

Department of Macromolecular Science, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China; National Nanotechnology Center (NaNOTEC), National Science and Technology Development agency, Pathumthani, 12120, Thailand

Type

Article

Source Title

Scientific Reports

ISSN

20452322

Year

2018

Volume

8

Issue

1

Open Access

All Open Access, Gold, Green

Publisher

Nature Publishing Group

DOI

10.1038/s41598-018-23744-1

Format

PDF

Abstract

an available pathway to prepare the ionized covalent organic nanosheets (iCONs) has been proposed by a metal-assisted aqueous-phase exfoliation route from covalent organic frameworks. The soluble and belt-shaped iCONs could immobilize a large quantity of proteins (2.73 mg/mg, BSa/iCONs) and hence serve as transporters to enhance the protein uptake by cancer cells. Meanwhile, their energy-dependent endocytosis pathway via clathrin-coated pits has been proved as well. © 2018 The author(s).

Industrial Classification

N/A

Knowledge Taxonomy Level 1

N/A

Knowledge Taxonomy Level 2

N/A

Knowledge Taxonomy Level 3

N/A

Funding Sponsor

National Natural Science Foundation of China; Science and Technology Commission of Shanghai Municipality

License

CC BY

Rights

Author

Publication Source

Scopus

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